Intracellular survival and expression of virulence determinants of Legionella pneumophila
نویسندگان
چکیده
منابع مشابه
Association of flagellum expression and intracellular growth of Legionella pneumophila.
We examined the role of the flagella of Legionella pneumophila in the infection of amoebae and human monocyte-like cells. Insertional mutants were constructed with mini-Tn10. Ten mutants (F-) which did not react with polyclonal L. pneumophila antiflagellar antisera were identified. Ten randomly selected mutants (F+) that did react with the polyclonal antiflagellar antiserum were also identified...
متن کاملIntracellular parasitism and molecular determinants of Legionella virulence.
Bacteria of the genus Legionella are intracellular parasites and major human pathogens. They bind to surface receptors, penetrate eukaryotic cells and initiate complex disorders during phagocytosis. These disorders include inhibition of oxidative burst, a decrease in phagosome acidification, the blocking of phagosome maturation and changes in organelle trafficking. As a result, the microorganis...
متن کاملComparative analysis of Legionella pneumophila and Legionella micdadei virulence traits.
While the majority of Legionnaire's disease has been attributed to Legionella pneumophila, Legionella micdadei can cause a similar infection in immunocompromised people. Consistent with its epidemiological profile, the growth of L. micdadei in cultured macrophages is less robust than that of L. pneumophila. To identify those features of the Legionella spp. which are correlated to efficient grow...
متن کاملAnalysis of virulence factors of Legionella pneumophila.
Legionella pneumophila, the causative agent of Legionnaires' disease is a facultative intracellular bacterium, which in the course of human infection multiplies in lung macrophages predominantly manifesting as pneumonia. The natural habitat of Legionella is found in sweet water reservoirs and man-made water systems. Virulent L. pneumophila spontaneously convert to an avirulent status at a high ...
متن کاملAntimicrobial susceptibility of intracellular Legionella pneumophila.
Minimum inhibitory concentrations, minimum bactericidal concentrations, and killing curve assays were measured after Legionella pneumophila was grown in human lung fibroblasts. Results of susceptibility testing of organisms grown intracellularly are compared with results for organisms grown by standard tube dilution methods.
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ژورنال
عنوان ژورنال: Infection
سال: 1991
ISSN: 0300-8126,1439-0973
DOI: 10.1007/bf01644033